About Us: Research Affiliates

Contact


  • Office Location: 2208 Natural Sciences I
  • Mailing Address:
    UC Irvine Developmental and Cell Biology Irvine, CA 92697-2300
  • Office: 949.824.6902
Web: Home Page

Bardwell, Lee


Biography

Ph.D., Stanford University, 1992

Research

Using molecular biology, biochemistry, genetics, cell biology and math/computation to study fundamental questions of cell signaling and regulation. Regulation of mitogen-activated protein kinase (MAPK) cascades in yeast and mammalian cells. Mechanisms of specificity in signal transduction, especially protein kinase signaling. Signal transduction networks are a crucial part of the circuitry by which a cell regulates and coordinates its growth and developmental program, and its response to the external environment. Faulty or malfunctioning signaling pathways lie at the heart of the molecular pathology of many diseases, including cancer. The signaling components we study have been highly conserved through evolution, and are thus of great importance to basic biology, as well as medicine.

Labs

2403 Natural Sciences I