Events: Calendar

Miniscope Imaging of the Brain

Title: Miniscope Imaging of the Brain
Event Date: 3/9/2018 - 3/9/2018
Event Time: 11:45 a.m.
Event End: 1 p.m.

CALIT2, Room 3008


New and emerging technologies have been applied to neuroscience research. The miniaturized microscope (“miniscope”) is a fluorescent microscope, roughly the height of a Lego brick, which weighs less than 3 grams. As the miniscope is small and light, the animals move around with it very well. Prof. Xiangmin Xu’s laboratory has developed and applied head-mounted miniscopes to image hundreds of brain cells in one field of view in freely behaving mice. Miniature microscopic imaging of neural activities in the intact brain allows for studying how neural activities at single-cell resolution are associated with learning and memory, and spatial navigation. Prof. Xu will introduce this exciting imaging technique, and present their research toward understanding neural circuit mechanisms that underlie neurological disorders including Alzheimer's disease.

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Xiangmin Xu

My interests are in neural circuitry, which applies to understanding the neurobiology of sensory perception, learning and memory, and epilepsy.  Understanding how neural circuits give rise to perception, cognition, and behavior is central to understanding how the brain works.  This is also key to understanding the mechanistic basis of neurological disorders.  Our research is focused on understanding cell-type specific cortical circuit organization and function, using combined approaches of electrophysiology, optical stimulation and imaging, molecular genetics and viral tracing.  Our research program is funded by NIH grants and private foundation funds.